CD4+ T-Cell Lymphoma Harboring a Chimeric Antigen Receptor Integration in <i>TP53</i>.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 39908432.
- Also identified by DOI 10.1056/NEJMoa2411507 and PMC identifier 11801235.
- Licence recorded as CC BY-NC-ND.
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Abstract
Malignant T-cell transformation after chimeric antigen receptor (CAR) T-cell therapy has been described, but the contribution of CAR integration to oncogenesis is not clear. Here we report a case of a T-cell lymphoma harboring a lentiviral integration in a known tumor suppressor, <i>TP53</i>, which developed in a patient with multiple myeloma after B-cell maturation antigen (BCMA) CAR T-cell therapy.
Medical subject headings
- B-Cell Maturation Antigen
- Immunotherapy, Adoptive
- Lymphoma, T-Cell
- Multiple Myeloma
- Tumor Suppressor Protein p53