Vancomycin Concentrations in Umbilical Cord Blood After Intrapartum Exposure.
Where this comes from
- Record sourced from PubMed, PMID 39913929.
- Also identified by DOI 10.1097/AOG.0000000000005843.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Little is known about the fetal-neonatal pharmacokinetics of maternally administered, weight-based vancomycin dosing for group B streptococcus (GBS) intrapartum antibiotic prophylaxis. Our objective was to quantify vancomycin concentrations in umbilical cord blood at birth after weight-based maternal intrapartum vancomycin administration and to assess cord blood vancomycin levels relative to the established GBS clinical minimum inhibitory concentration (MIC) breakpoint. Using a convenience sample of stored sera from our biorepository, we measured vancomycin levels in umbilical cord blood from 26 neonates after maternal intrapartum vancomycin exposure. Most neonates (24/26, 92.3%; 95% CI, 74.9-99.1%) had vancomycin cord blood levels above the MIC breakpoint (1 microgram/mL or higher) for GBS.
Medical subject headings
- Fetal Blood
- Vancomycin
- Anti-Bacterial Agents
- Streptococcal Infections
- Pregnancy Complications, Infectious