Engineered Shape-Tunable Copper-Coordinated Nanoparticles for Macrophage Reprogramming.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 39914892.
- Also identified by DOI 10.1021/acs.nanolett.4c05999 and PMC identifier 11849021.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
The immune system safeguards as primary defense by recognizing nanomaterials and maintaining homeostasis, gaining a deeper understanding of these interactions may change the treating paradigm of immunotherapy. Here, we adopted copper as the principal component of nanoparticles (NPs), given its features of coordination with different benezenecarboxylate ligands to form metal-organic frameworks and complexes with distinct morphologies. As a result, four types of shape-tunable copper-coordinated NPs (CuCNPs) are developed: cuboctahedron, needle, octahedron, and plate NPs. Biocompatibility of CuCNPs varies across different cell lines (RAW264.7, THP-1, HEK 293 and HeLa) in a shape-dependent manner, with needle-shaped CuCNPs showing pronounced cytotoxicity (IC50:104.3 μg mL<sup>-1</sup> at 24 h). Among different shapes, a notable increase of 8.47% in the CD206<sup>+</sup> subpopulations is observed in needle-shaped CuCNPs, followed by 77% enhancement at 48 h. Overall, this study underscores the shape-dependent immune-regulatory effects of CuCNPs and sheds light on the rational design of nanoscale metal complexes for potential immunotherapy.
Medical subject headings
- Copper
- Macrophages
- Metal Nanoparticles
- Cellular Reprogramming
- Metal-Organic Frameworks