Is There a Winner? Prospective Randomized Controlled Trial Comparing SuperPulse Thulium Fiber Laser vs Pulse-Modulated High-Power Holmium:YAG Laser for Retrograde Intrarenal Surgery.

Abstract

Pulse-modulated holmium:YAG (Ho:YAG) and SuperPulse thulium fiber laser are high-power laser systems used for retrograde intrarenal surgery. We conducted a prospective randomized trial to compare lithotripsy efficiency, complications, and stone-free rates. Patients with CT-confirmed intrarenal stones between 5 and 20 mm were randomly assigned to pulse-modulated Ho:YAG (Moses 2.0, 120 W) or SuperPulse thulium fiber laser (60 W). The primary outcome was absolute (0 fragment) stone-free rate 6 weeks postoperatively evaluated by CT. Secondary outcomes included residual fragment size, laser efficiency, and postoperative complications. Categorical variables were compared using χ² or Fisher exact tests. Continuous variables were analyzed with Mann-Whitney <i>U</i> tests. Sixty-six patients were randomized to pulse-modulated Ho:YAG (n = 33) or SuperPulse thulium fiber laser (n = 33). Absolute stone-free rates were 79% and 82%, respectively (<i>P</i> = .8). Less than 3 mm residual fragments were observed in 18% and 6.1% (<i>P</i> = .3) and ≥ 3 mm residual fragments in 3% and 12% (<i>P</i> = .4), respectively. Total energy used (3.4 vs 3.1 kJ, <i>P</i> = .8) and lasing time (9.4 vs 12.8 minutes, <i>P</i> = .3) were similar. Laser ablation efficiency (0.038 vs 0.055 mm³/J, <i>P</i> = .16), laser activity (46% vs 56%, <i>P</i> = .07), and laser ablation speed (0.40 vs 0.42 mm³/s, <i>P</i> > .9) did not differ. Emergency department visits (3.0% vs 6.1%, <i>P</i> > .9) and complications (6.1% vs 9.1%, <i>P</i> > .9) were similar. We found no discernible differences between the high-power pulse-modulated Ho:YAG and SuperPulse thulium fiber laser for treatment of renal stones between 5 and 20 mm in terms of stone-free rates by CT scan, laser efficiency, and complications in our single-center study.