Human iPSCs offer an alternative for modeling vascular malformation.
basic_science · Level V
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- Record sourced from PubMed, PMID 39919719.
- Also identified by DOI 10.1016/j.stem.2025.01.008.
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Abstract
In this issue of Cell Stem Cell, Pan et al. generated human induced pluripotent stem cell (iPSC)-derived venous endothelial cells (iVECs) by manipulating cell-cycle dynamics and Notch signaling and demonstrated that TIE2-mutant iVECs recapitulate the pathogenesis of venous malformations.<sup>1</sup> Their study provides a model for further mechanistic studies and drug discovery.
Medical subject headings
- Induced Pluripotent Stem Cells
- Vascular Malformations
- Models, Biological