Multifunctional Hydrogel Electronics for Synergistic Therapy and Visual Monitoring in Wound Healing.

Abstract

To overcome the limitations of precise monitoring and inefficient wound exudate management in wound healing, an advanced multifunctional hydrogel electronics (MHE) platform based on MXene@MOF/Fe₃O₄@C photonic crystal hydrogel is developed. This platform combines optical/electrical sensing, synergistic therapy, and real-time visual monitoring into a single, efficient system, offering a comprehensive solution for wound healing. Under photothermal stimulation, the hydrogel releases metal ions that generate hydroxyl radicals, effectively eliminating antibiotic-resistant bacteria. Beyond its antibacterial efficacy, this system offers unprecedented real-time monitoring through temperature-responsive visualization, while structural color changes upon wound exudate absorption provide a clear indication for dressing replacement. By integrating these functionalities, MHE platform allows for precise control of the therapeutic process, significantly improving wound healing and treatment monitoring. The platform's optical/electrical sensing capabilities further broaden its potential applications across other biomedical fields. This breakthrough technology provides clinicians with a powerful tool to optimize therapeutic outcomes, marking a major advancement in wound care and biomedical applications.