Nitrogen-Doped Ultrananocrystalline Diamond - Optoelectronic Biointerface for Wireless Neuronal Stimulation.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 39935067.
- Also identified by DOI 10.1002/adhm.202403901 and PMC identifier 11973940.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
This study presents a semiconducting optoelectronic system for light-controlled non-genetic neuronal stimulation using visible light. The system architecture is entirely wireless, comprising a thin film of nitrogen-doped ultrananocrystalline diamond directly grown on a semiconducting silicon substrate. When immersed in a physiological medium and subjected to pulsed illumination in the visible (595 nm) or near-infrared wavelength (808 nm) range, charge accumulation at the device-medium interface induces a transient ionic displacement current capable of electrically stimulating neurons with high temporal resolution. With a measured photoresponsivity of 7.5 mA W<sup>-1</sup>, the efficacy of this biointerface is demonstrated through optoelectronic stimulation of degenerate rat retinas using 595 nm irradiation, pulse durations of 50-500 ms, and irradiance levels of 1.1-4.3 mW mm<sup>-2</sup>, all below the safe ocular threshold. This work presents the pioneering utilization of a diamond-based optoelectronic platform, capable of generating sufficiently large photocurrents for neuronal stimulation in the retina.
Medical subject headings
- Diamond
- Nitrogen
- Neurons
- Wireless Technology