High Prevalence of Ceftriaxone-Resistant Neisseria gonorrhoeae in Hanoi, Vietnam, 2023-2024.
cross_sectional · Level IV
Where this comes from
- Record sourced from PubMed, PMID 39938052.
- Also identified by DOI 10.1093/infdis/jiaf071 and PMC identifier 12308657.
- Licence recorded as CC BY-NC-ND.
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Abstract
Ceftriaxone resistance in Neisseria gonorrhoeae is an escalating global health concern, threatening the efficacy of empiric treatment. In the Asia-Pacific region, a rapid surge in ceftriaxone resistance has been observed, primarily associated with the penA-60.001 allele. This study, conducted in Hanoi, Vietnam between 2023 and 2024, analyzed 352 N. gonorrhoeae isolates and found a 27% prevalence of ceftriaxone resistance. Whole-genome sequencing identified that resistance was predominantly driven by the mosaic penA-237.001 allele, with a smaller contribution from penA-60.001. The high prevalence of resistance and the emergence of new alleles underscore the urgent threat to ceftriaxone as an empiric treatment option.
Medical subject headings
- Neisseria gonorrhoeae
- Ceftriaxone
- Gonorrhea
- Anti-Bacterial Agents
- Drug Resistance, Bacterial