A biodegradable capacitive-coupling neurostimulator for wireless electroceutical treatment of inflammatory bowel diseases.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 39951521.
- Also identified by DOI 10.1126/sciadv.adu5887 and PMC identifier 11827631.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Electroceuticals based on peripheral nerve stimulation offer promising treatment for refractory inflammatory diseases such as inflammatory bowel diseases (IBDs). For pediatric IBD (PIBD) patients, wireless, biodegradable miniaturized bioelectronic devices are crucial to prevent neural damage and support neural development during and after therapy. Here we demonstrate a battery-free, miniaturized neurostimulator based on biodegradable materials and capacitive-coupling wireless power transfer. The biodegradable capacitive-coupling (BCC) neurostimulator consists of molybdenum (Mo) electronic components and self-healing biodegradable polyurethane elastomer (SBPUE) encapsulations. The self-healing property of SBPUE enables a stable neural interface. Capacitive coupling wirelessly transfers high-frequency electric fields through a single capacitor between wearable transmitters and implanted BCC neurostimulators. Programmed electrical stimulation of the vagus nerve alleviates PIBD symptoms by restoring CD4<sup>+</sup> T cell balance, enhancing anti-inflammatory effects and suppressing pro-inflammatory effects in the intestines.
Medical subject headings
- Inflammatory Bowel Diseases
- Wireless Technology
- Electric Stimulation Therapy
- Implantable Neurostimulators