The N-type calcium channel rises from the ashes.
editorial · Level V
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- Record sourced from PubMed, PMID 39959970.
- Also identified by DOI 10.1172/JCI189308 and PMC identifier 11827886.
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Abstract
Chronic pain is a debilitating condition that affects up to 1.5 billion people globally. Advancing pain management depends on a thorough understanding of the types of pain experienced by patients and the underlying mechanisms driving it. N-type calcium channels play a crucial role as therapeutic targets for managing chronic pain. In this issue of the JCI, Tang et al. introduce C2230, an N-type calcium channel blocker that inhibited CaV2.2 channels during high frequency stimulation with little effect on other ion channels in the pain pathway across multiple models. C2230 offers a promising analgesic for use in therapeutic intervention.
Medical subject headings
- Calcium Channels, N-Type
- Calcium Channel Blockers
- Chronic Pain