A roadmap to precision medicine through post-genomic electronic medical records.

Mendez, Kevin M; Reinke, Stacey N; Kelly, Rachel S; Chen, Qingwen; Su, Mark; McGeachie, Michael; Weiss, Scott; Broadhurst, David I et al. · Nat Commun · 2025

review · Level V

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Abstract

The promise of integrating Electronic Medical Records (EMR) and genetic data for precision medicine has largely fallen short due to its omission of environmental context over time. Post-genomic data can bridge this gap by capturing the real-time dynamic relationship between underlying genetics and the environment. This perspective highlights the pivotal role of integrating EMR and post-genomics for personalized health, reflecting on lessons from past efforts, and outlining a roadmap of challenges and opportunities that must be addressed to realize the potential of precision medicine.

Medical subject headings