Glucose-6-Phosphate Dehydrogenase Deficiency Is Associated With Increased Risk of Acute Kidney Injury Independent of Hemolytic Complications in Children With Severe Malaria.
case_control · Level III
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- Record sourced from PubMed, PMID 39963714.
- Also identified by DOI 10.1093/infdis/jiaf080 and PMC identifier 12308644.
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Abstract
Acute kidney injury (AKI) is common and predicts mortality in severe malaria. Studies have reported an increased incidence of AKI in males with hemolytic features of severe malaria. Glucose-6-phosphate dehydrogenase (G6PD) deficiency, an X-linked enzymopathy, can induce hemolysis. We evaluated whether the G6PD African allele (A-) was associated with AKI in children with severe malaria. The prevalence of G6PD deficiency was 16.7% among hemizygous male children and 2.4% in female children. G6PD deficiency was associated with 2.56-fold odds of AKI (95% confidence interval, 1.33-4.93; P = .005), adjusting for age, sex, site, nutritional status, and features of hemolysis.
Medical subject headings
- Glucosephosphate Dehydrogenase Deficiency
- Acute Kidney Injury
- Malaria