Do we know more about the mechanobiology of the intervertebral disc in space than on Earth?
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 39968355.
- Also identified by DOI 10.1002/jsp2.70024 and PMC identifier 11834163.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
This work provides a perspective on the loading protocols used in whole-organ interverterbal disc culture studies using bioreactors. We put this in the context of in vivo spinal loading, and we put forward the case that the majority of previous bioreactor studies have more in common with spinal loading in space than on Earth. Finally, we provide an outlook for the future of bioreactor research, to provide data more relevant to spinal loading on Earth, and maximize the translational potential of findings to the clinical setting.