Near-critical corticothalamic eigenmodes: Effects of nonuniform connectivity on modes, activity, and communication channels.

Abstract

The effects of nonuniformities in axonal connectivity on natural modes of brain activity are explored to determine their contributions to modal eigenvalues, structure, and communication and to clarify the limits of validity of widely used uniform-connectivity approximations. Preferred channels of communication are demonstrated that are supported by natural modes of mean connectivity and resulting activity. The effects of axonal tracts on these modes are calculated using perturbation methods, and it is found that modes and their spectra are only moderately perturbed by even the largest white matter tracts. However, perturbations of activity are greatly magnified when modes are near-critical and realistic connectivity and gain perturbations can then enable rapid responses to stimuli on the observed timescales of evoked responses. It is thus argued that dynamic mode-mode communication channels complement ones based on white matter tracts and that both rely on near-criticality to have their observed effects.