Natural History of Chapare Virus Infection in Strain 13 Guinea Pigs.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 39980339.
- Also identified by DOI 10.1093/infdis/jiaf081 and PMC identifier 12128047.
- Licence recorded as CC BY-NC-ND.
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Abstract
Chapare virus (CHAPV) is an emerging arenavirus first discovered in Bolivia. Clinical cases have a high case-fatality rate and a concerning capacity for person-to-person spread. Animal models of Chapare hemorrhagic fever are needed to study pathogenesis and development of medical counter measures. Here, we present a narrowly focused study describing lethal infection of strain 13 guinea pigs with CHAPV. Animals challenged with CHAPV had progressive weight loss, lymphocytopenia, neutropenia, thrombocytopenia, hepatitis, vascular leakage, and gastrointestinal hemorrhage, resulting in uniform lethality between 7 and 16 days following challenge. This work lays the foundation for development of a small animal model of CHAPV infection.
Medical subject headings
- Disease Models, Animal
- Arenaviridae Infections
- Arenaviruses, New World
- Hemorrhagic Fever, American