Concomitant ATTR and AL Cardiac Amyloidosis With Matching 99m Tc-DPD Scintigraphy and 18 F-Flutemetamol PET/CT.

O, Joo Hyun; Youn, Jong-Chan; Han, Eun Ji; Jung, Mi-Hyang; Lee, Jung Yeon; Park, Sung-Soo; Sung, Yeoun Eun; Min, Chang-Ki · Clin Nucl Med · 2025

case_report · Level V

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Abstract

Two distinct types of systemic amyloidosis-transthyretin (ATTR) and light chain (AL)-account for the majority of cardiac amyloidosis (CA), which have been considered mutually exclusive. Diagnostic confusion can arise when both proteins are identified from an amyloid deposit. We present a rare occurrence of histopathologically confirmed concomitant ATTR and AL CA captured on 99m Tc-3,3-diphosphono-1,2-propanodicarboxylic acid (DPD) scan and 18 F-flutemetamol (FMM) PET/CT.

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