FDG PET/CT of Atypical Myeloid Sarcoma After CAR T-Cell Therapy.
case_report · Level V
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- Record sourced from PubMed, PMID 39988793.
- Also identified by DOI 10.1097/RLU.0000000000005759.
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Abstract
A 23-year-old man with a history of Ph-Like B-cell acute lymphoblastic leukemia (B-ALL) with JAK2 rearrangement presented with innumerable skin lesions developing over 1 week. Before presentation, he had multiple relapses of his B-ALL and underwent autologous UCD-19 chimeric antigen receptor (CAR) T-cell therapy. Lesions appeared 1.5 months after completion of therapy. Biopsies showed new onset myeloid sarcoma (MS), with continued remission of B-ALL. 18 F-FDG PET/CT showed numerous markedly hypermetabolic soft tissue lesions located in the skin and subcutaneous tissues, muscles, osseous structures, mucosa, pleura, mediastinum, peritoneum, retroperitoneum, and testes.
Medical subject headings
- Positron Emission Tomography Computed Tomography
- Fluorodeoxyglucose F18
- Sarcoma, Myeloid
- Receptors, Chimeric Antigen
- Immunotherapy, Adoptive