Untangling a case of dapsone-induced acute liver injury.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 39989583.
- Also identified by DOI 10.4103/jfmpc.jfmpc_885_24 and PMC identifier 11844990.
- Licence recorded as CC BY-NC-SA.
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Abstract
Dapsone hypersensitivity syndrome, although rare, may manifest with fever, rash, and multi-organ failure, mimicking other common diseases. This case study involves a 9-year-old female patient presenting with fever and acute liver injury, in which the intake of dapsone was not revealed until much later. We discuss how the diagnosis was made and the successful outcome following prompt treatment. A high index of suspicion and vigilant history-taking, along with a detailed past treatment history, can provide early clues in reaching a diagnosis. Early intervention with systemic corticosteroids improves the outcome of dapsone hypersensitivity syndrome and can prevent mortality.