A column-like organization for ocular dominance in mouse visual cortex.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 40000624.
- Also identified by DOI 10.1038/s41467-025-56780-3 and PMC identifier 11861588.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
The columnar organization of response properties is a fundamental feature of the mammalian visual cortex. However, columns have not been observed universally across all mammalian species. Here, we report the discovery of clusters of ipsilateral eye preferring neurons in layer 4 of the mouse primary visual cortex. These clusters extend into layer 2/3 and upper layer 5, forming a column-like pattern for ocular dominance. Our observation of such structures in this minute cortical area sets a new boundary condition for models explaining the emergence of functional organizations in the neocortex.
Medical subject headings
- Dominance, Ocular
- Visual Cortex
- Neurons
- Primary Visual Cortex