Synthetic molecular communication through microfluidic oscillating droplets for intrabody physiological data transmission.

Abstract

We explore the capabilities of a microfluidic-based synthetic molecular communication (SMC) system for the transmission of physiological data within the human body. The system employs oscillating water droplets as a means of transmitting information through pressure variations. The validity of this approach for binary communications is validated through a combination of simulations and experiments. A case study focused on monitoring gastroesophageal reflux disease (GERD) has been considered. The prototype platform demonstrated the capacity to transmit both synthetic raw esophageal pH values and severity classifications (<i>e.g.</i> acid reflux) through oscillating droplets. This finding underscores the promise of SMC for real-time physiological monitoring, paving the way for enhanced disease diagnosis and personalized treatment in medicine. Despite the need for miniaturization to facilitate <i>in vivo</i> use, this research establishes a robust foundation for the development of microfluidic SMC devices for medical diagnostics and physiological monitoring.