<sup>13</sup>C hyperpolarization with nitrogen-vacancy centers in micro- and nanodiamonds for sensitive magnetic resonance applications.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 40020059.
- Also identified by DOI 10.1126/sciadv.adq6836 and PMC identifier 11870072.
- Licence recorded as CC BY-NC.
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Abstract
Nuclear hyperpolarization is a known method to enhance the signal in nuclear magnetic resonance (NMR) by orders of magnitude. The present work addresses the <sup>13</sup>C hyperpolarization in diamond micro- and nanoparticles, using the optically pumped nitrogen-vacancy center (NV) to polarize <sup>13</sup>C spins at room temperature. Consequences of the small particle size are mitigated by using a combination of surface treatment improving the <sup>13</sup>C relaxation (<i>T</i><sub>1</sub>) time, as well as that of NV, and applying a technique for NV illumination based on a microphotonic structure. Adjustments to the dynamical nuclear polarization sequence (PulsePol) are performed, as well as slow sample rotation, to improve the NV-<sup>13</sup>C polarization transfer rate. The hyperpolarized <sup>13</sup>C NMR signal is observed in particles of 2-micrometer and 100-nanometer median sizes, with enhancements over the thermal signal (at 0.29-tesla magnetic field) of 1500 and 940, respectively. The present demonstration of room-temperature hyperpolarization anticipates the development of agents based on nanoparticles for sensitive magnetic resonance applications.