Primary low-grade salivary gland-type intraductal carcinoma of the lung with CCDC6::RET fusion: Case presentation and literature review.
case_report · Level V
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- Record sourced from PubMed, PMID 40036626.
- Also identified by DOI 10.1093/ajcp/aqaf014.
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Abstract
Salivary gland-type intraductal carcinoma (IC) is a rare type of low-grade salivary gland neoplasm. Given that the clinical and imaging features of primary lung IC are nonspecific, the diagnosis requires pathologic analysis. We report a 63-year-old woman with primary low-grade salivary gland-type IC of the lung, characterized by an origin from the bronchus submucosa, an intraductal or intracavity growth of ductal epithelium, an absence of interstitial infiltration, and harboring an RET::CCDC6 fusion. Through case presentation and a literature review, we discuss the differential diagnosis and clinical management of salivary gland-type IC of the lung. Molecular testing is not necessary for histologic subtyping but can aid in the differential diagnosis of IC.
Medical subject headings
- Lung Neoplasms
- Proto-Oncogene Proteins c-ret
- Carcinoma, Intraductal, Noninfiltrating