Famsin and fasting adaptation: A glucagon connection.

Li, Siming; Meng, Ziyi; Lin, Jiandie D · Cell Metab · 2025

editorial · Level V

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Abstract

Starvation triggers an organismal adaptive response that is orchestrated by endocrine factors. In this issue of Cell Metabolism, Long et al.<sup>1</sup> uncover a famsin-glucagon axis that relays gut-derived hormonal cues to systemic glucose homeostasis during fasting.

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