SnapShot: Brain-targeting anti-obesity medications.

Petersen, Jonas; Ingemann Johansen, Valdemar Brimnes; Clemmensen, Christoffer · Cell Metab · 2025

review · Level V

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Abstract

Advances in the understanding of homeostatic regulation of body weight and the neurobiology of appetite, combined with innovations in medicinal chemistry, have paved the way for safe and effective weight loss medications. Long-acting GLP-1 receptor agonists have revolutionized obesity treatment, and, together with emerging GLP-1-based multi-agonists and combination therapies, offer significant potential to combat cardiometabolic diseases and a range of other chronic health challenges. To view this SnapShot, open or download the PDF.

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