Can 99m Tc-PSMA SPECT/CT Presenting Mirror Image of 68 Ga-PSMA PET/CT Be Used for Response Assessment to 177 Lu-PSMA in Metastatic Castration-Resistant Prostate Cancer?
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- Record sourced from PubMed, PMID 40051079.
- Also identified by DOI 10.1097/RLU.0000000000005754.
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Abstract
A 69-year-old man, with a known case of metastatic castration-resistant prostate cancer (mCRPC) underwent 68 Ga-PSMA PET/CT and 99m Tc-PSMA for evaluation of disease burden and response assessment to 177 Lu-PSMA therapy. 99m Tc-PSMA provided a mirror image of 68 Ga-PSMA. This suggests the potential of 99m Tc-PSMA SPECT/CT for disease evaluation and response assessment to PSMA-based radioligand therapies in advanced-stage mCRPC patients, especially when 68Ga-PSMA PET/CT is not available.
Medical subject headings
- Prostatic Neoplasms, Castration-Resistant
- Lutetium
- Positron Emission Tomography Computed Tomography
- Single Photon Emission Computed Tomography Computed Tomography
- Organotechnetium Compounds