Overcoming gene dosage barriers in mammalian development: An imprinting balancing act.
basic_science · Level V
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- Record sourced from PubMed, PMID 40054450.
- Also identified by DOI 10.1016/j.stem.2025.02.005.
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Abstract
Genomic imprinting ensures parent-of-origin gene expression and prevents uniparental development. In this issue of Cell Stem Cell, Li et al.<sup>1</sup> extensively engineered androgenic haploid embryonic stem cells to overcome imprinting barriers, producing adult bi-paternal mice, albeit with low efficiency, and providing insights into roles of imprinted genes in development.
Medical subject headings
- Genomic Imprinting
- Gene Dosage
- Mammals