PSPC1 bridges cancer stemness and malignancy in acute myeloid leukemia.
review · Level V
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- Record sourced from PubMed, PMID 40054451.
- Also identified by DOI 10.1016/j.stem.2025.02.006.
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Abstract
In a recent publication in Cell Stem Cell, Hong et al.<sup>1</sup> uncovered paraspeckle component 1 (PSPC1) as a determinant of leukemogenic characteristics in acute myeloid leukemia (AML). PSPC1 is not essential for normal hematopoiesis but it is upregulated to interact with PU.1 to promote AML progression and is also emerging as a therapeutic target.
Medical subject headings
- Leukemia, Myeloid, Acute
- Neoplastic Stem Cells
- Nuclear Proteins
- RNA-Binding Proteins