Stripe out for brain evolution: Astrocytes go human.

López-González, Lara; Borrell, Víctor · Cell Stem Cell · 2025

basic_science · Level V

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Abstract

Evolution of the human brain involved neuron and glial cell changes. In this issue of Cell Stem Cell, Ciuba et al.<sup>1</sup> identify an epigenetic mechanism central in the evolution of human astrocytes, where small enhancer modifications increased transcription factor binding, orchestrating transcriptomic changes that influence astrocyte structure and function.

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