Intense Uptake of 68 Ga-exendin-4 in a Patient With WHO Grade 3 Insulinoma and Extensive Intrahepatic Metastases.
case_report · Level V
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- Record sourced from PubMed, PMID 40065404.
- Also identified by DOI 10.1097/RLU.0000000000005834.
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Abstract
A 24-year-old woman with hyperinsulinemic hypoglycemia was found with a pancreatic mass and multiple intrahepatic lesions in CT and MRI. 68 Ga-exendin-4 PET/CT showed intense radioactivity in the pancreatic mass and all the intrahepatic lesions, suggesting a malignant insulinoma with multiple intrahepatic metastases. Subsequent fine needle biopsy confirmed the diagnosis of WHO grade 3 insulinoma. This case with extensive glucagon-like peptide-1 receptor (GLP-1R) expression in a high-grade malignant insulinoma highlighted the potential of GLP-1R-targeted PRRT in future clinical studies.
Medical subject headings
- Insulinoma
- Liver Neoplasms
- Pancreatic Neoplasms
- Venoms