Unintegrated HIV-1 DNA recruits cGAS via its histone-binding domain to escape innate immunity.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 40067888.
- Also identified by DOI 10.1073/pnas.2424465122 and PMC identifier 11929445.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
To ensure optimal replication and spread, viruses have evolved countermeasures to evade type 1 IFN-mediated antiviral activity. During the early viral replication cycle steps until uncoating, the HIV-1 core protects viral pathogen associated molecular patterns (viral RNA and reverse transcription products) from recognition by innate immune sensors, including cGAS. However, after capsid uncoating, unintegrated viral DNA (uvDNA) becomes accessible. Here, we show that HIV-1 uses chromatin-mediated cGAS inactivation as a mechanism to protect its uvDNA from innate immune activation.
Medical subject headings
- Immunity, Innate
- HIV-1
- Nucleotidyltransferases
- DNA, Viral
- Histones
- HIV Infections
- Immune Evasion