Electroactive Dressing with Selective Sorption of Exudate Enables Treatment of Complicated Wound.

Abstract

Exudate management and cell activity enhancement are vital to complicated wound healing. However, current exudate management dressings indiscriminately remove exudate, which is detrimental to cell activity enhancement. Herein, a novel class of electroactive bilayer (cMO/PVA) dressing is developed by constructing manganese oxide nanoneedle-clusters decorated commercial carbon cloth (MO), in situ casting polyvinyl alcohol (PVA) hydrogel, and finally charging. Benefitting from the hierarchical nanoneedle-cluster structure of MO, abundant active sites are sufficiently exposed to achieve high area-specific capacitances (e.g., 1881.3 mF cm^-2), thereby establishing the long-lasting electric field for cMO/PVA dressing. Such a unique cMO/PVA dressing can realize extraordinary selective sorption toward noxious substances over nutrient substances during exudate management. Meanwhile, its long-term electrical stimulation therapy can promote cell proliferation and migration and enhance antibacterial property. As a result, our multifunctional cMO/PVA dressing can rapidly repair full-thickness wounds in type II diabetic rats, offering an advanced strategy for the treatment of complicated wounds.