Single-Atom Cu Anchored on Carbon Nitride as a Bifunctional Glucose Oxidase and Peroxidase Nanozyme for Antibacterial Therapy.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 40087138.
- Also identified by DOI 10.1021/acsnano.4c12348 and PMC identifier 11948616.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
A very promising strategy to avoid bacterial drug resistance is to replace antibiotics with artificial nanozymes, but this has not yet been translated to the clinic. Here, we construct a single-atom nanozyme using graphitic carbon nitride nanosheets modified by copper (Cu-<i>g</i>-C<sub>3</sub>N<sub>4</sub>). This Cu-<i>g</i>-C<sub>3</sub>N<sub>4</sub> nanosheet possesses both glucose oxidase-like and peroxidase-like activities responsible for reactive-oxygen-species generation by a cascade reaction to eradicate Gram-positive and Gram-negative multidrug-resistant bacteria. Cu-<i>g</i>-C<sub>3</sub>N<sub>4</sub> is introduced into polycaprolactone (PCL) by electrospinning to obtain (Cu-<i>g</i>-C<sub>3</sub>N<sub>4</sub>/PCL) nanofibers, which can be used as a dressing for bacterially infected wounds. It is demonstrated that Cu-<i>g</i>-C<sub>3</sub>N<sub>4</sub>/PCL nanofiber dressings can eradicate bacterial infections and accelerate wound healing in a mouse model with a skin wound.
Medical subject headings
- Copper
- Anti-Bacterial Agents
- Glucose Oxidase
- Nitriles
- Peroxidase
- Nitrogen Compounds