AlphaPulldown2-a general pipeline for high-throughput structural modeling.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 40088942.
- Also identified by DOI 10.1093/bioinformatics/btaf115 and PMC identifier 11937959.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
AlphaPulldown2 streamlines protein structural modeling by automating workflows, improving code adaptability, and optimizing data management for large-scale applications. It introduces an automated Snakemake pipeline, compressed data storage, support for additional modeling backends like UniFold and AlphaLink2, and a range of other improvements. These upgrades make AlphaPulldown2 a versatile platform for predicting both binary interactions and complex multi-unit assemblies. AlphaPulldown2 is freely available at https://github.com/KosinskiLab/AlphaPulldown.
Medical subject headings
- Software
- Proteins
- Models, Molecular
- Computational Biology