A TaSnRK1α-TaCAT2 model mediates resistance to Fusarium crown rot by scavenging ROS in common wheat.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 40089587.
- Also identified by DOI 10.1038/s41467-025-57936-x and PMC identifier 11910652.
- Licence recorded as CC BY-NC-ND.
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Abstract
Fusarium crown rot (FCR) is a serious underlying disease to threaten wheat yield and quality recently. Here, we identify a catalase antioxidant enzyme (TaCAT2) through genome wide association study (GWAS) and whole-exome sequencing (WES) in two nested bi-parental populations. We verify the function of TaCAT2 regulating wheat FCR resistance by genetic transformation. Moreover, we screen a sucrose non-fermenting-1-related protein kinase alpha subunit (TaSnRK1α) interacting with TaCAT2, and subsequently find that TaSnRK1α phosphorylates TaCAT2. We next identify an FCR-resistance haplotype TaCAT2<sup>Ser214</sup>, and confirm that Ser214 of TaCAT2 is a key phosphorylation site for TaSnRK1α. We also find that TaSnRK1α results in higher protein accumulation in TaCAT2<sup>Ser214</sup> than in TaCAT2<sup>Thr214</sup>, which possibly contribute to scavenging ROS (reactive oxygen species) in TaCAT2<sup>Ser214</sup> wheat plants. Furthermore, the function of TaSnRK1α regulating FCR resistance is verified by genetic transformation. Taken together, we propose a TaSnRK1α-TaCAT2 model to mediate FCR resistance by scavenging the ROS in wheat plants.
Medical subject headings
- Triticum
- Fusarium
- Plant Diseases
- Reactive Oxygen Species
- Disease Resistance
- Plant Proteins
- Protein Serine-Threonine Kinases
- Catalase