18 F-FDG-avid Myelophthisis : A Caveat Unveiling Occult Signet-ring Cell Gastric Carcinoma.
case_report · Level V
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- Record sourced from PubMed, PMID 40098044.
- Also identified by DOI 10.1097/RLU.0000000000005748.
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Abstract
Disseminated 18 F-FDG-avid intraosseous lesions and clumps of malignant signet-ring cells on subsequent bone marrow aspirate were detected upon investigation of a 58-year-old man with intolerable bone pain, normocytic anemia, and elevated serum alkaline phosphatase. Immunohistochemistry and gastroscopic biopsy confirmed mucin-rich signet-ring cell adenocarcinoma [signet-ring cell gastric carcinoma (SRGC)]. Intriguingly, synchronous bone secondaries from SRGC tend to be hypermetabolic, regardless of the primary tumor 18 F-FDG-negativity, insinuating a reverse heterogeneity of tumor molecular biology. The identification of 18 F-FDG-avid myelophthisis on the setting of bone pain constitutes a caveat for suspicion of cancerous lesions from SRGC and should urge for bone marrow biopsy to improve treatment implications.
Medical subject headings
- Carcinoma, Signet Ring Cell
- Stomach Neoplasms
- Fluorodeoxyglucose F18
- Bone Marrow