Low Incidence of Varicella in Pediatric Patients With Inflammatory Bowel Disease.
retrospective_cohort · Level III
Where this comes from
- Record sourced from PubMed, PMID 40099768.
- Also identified by DOI 10.14309/ajg.0000000000003418.
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Abstract
Immune-modifying therapies in pediatric inflammatory bowel disease (IBD) increase infection risks, including varicella. Using Optum's deidentified Clinformatics Data Mart Database, a nationwide US commercial insurance claims database (2007-2022), we conducted a retrospective study of 5,368 patients with IBD aged 21 years or younger matched to a non-IBD cohort. The primary outcome was incidence of varicella. Varicella incidence was low in both groups (IBD: 0.570 vs non-IBD: 0.297 per 1,000 person-years, P = 0.23). At year 4, cumulative varicella incidence was 0.27% for IBD and 0.18% for non-IBD ( P = 0.24). No hospitalizations or deaths occurred. Despite immune-modifying therapy, pediatric patients with IBD demonstrate low varicella incidence.
Medical subject headings
- Chickenpox
- Inflammatory Bowel Diseases