Recovery of Antibody Immunity After a Resurgence of Respiratory Syncytial Virus Infections.
prospective_cohort · Level II
Where this comes from
- Record sourced from PubMed, PMID 40099894.
- Also identified by DOI 10.1093/infdis/jiaf101 and PMC identifier 12128052.
- Licence recorded as CC BY-NC-ND.
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Abstract
Longitudinal measurements of respiratory syncytial virus (RSV) immunity over 4 winter seasons reveal that viral neutralization titers, RSV prefusion F protein (pre-F)-specific immunoglobulin M and immunoglobulin G (IgG) levels, and RSV antibody-dependent cellular phagocytosis function gradually returned to prepandemic levels in female healthcare and school workers of childbearing age after 2 winter seasons, following the resurgence of RSV cases in the Vancouver metropolitan region (British Columbia, Canada). In contrast, pre-F IgG avidity profiles remained unchanged. These findings support the notion that repeated viral infections are necessary to maintain high RSV antibody levels in the population.
Medical subject headings
- Respiratory Syncytial Virus Infections
- Antibodies, Viral
- Respiratory Syncytial Virus, Human
- Respiratory Syncytial Viruses