Targeting pathogenic interferon-stimulated gene RSAD2 improves pregnancy outcomes in systemic lupus erythematosus models.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 40107239.
- Also identified by DOI 10.1016/j.xcrm.2025.102034 and PMC identifier 11970377.
- Licence recorded as CC BY-NC-ND.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Excessive type I interferons during pregnancy are associated with poor pregnancy outcomes. Ding et al.<sup>1</sup> demonstrate the pathogenic effects of the interferon-stimulated gene RSAD2 that drives adverse pregnancy outcomes through placental lipid accumulation, and further identify a promising therapeutic candidate.
Medical subject headings
- Lupus Erythematosus, Systemic
- Pregnancy Outcome