Global surveillance and countermeasures for ACE2-using MERS-related coronaviruses with spillover risk.
editorial · Level V
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- Record sourced from PubMed, PMID 40118031.
- Also identified by DOI 10.1016/j.cell.2025.02.004.
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Abstract
Three studies published in this issue of Cell reveal that multiple MERS-related coronaviruses (MERSr-CoVs) utilize ACE2, rather than the canonical Merbecovirus receptor DPP4, for cell entry. These ACE2-dependent MERSr-CoVs pose a risk of zoonotic transmission to humans with high transmissibility potential like SARS-CoV-2, thus calling for global surveillance and countermeasures.
Medical subject headings
- Middle East Respiratory Syndrome Coronavirus
- Angiotensin-Converting Enzyme 2
- Coronavirus Infections