An Integrated Janus Bioelectronic Bandage for Unidirectional Pumping and Monitoring of Wound Exudate.

Abstract

Single-functional wound dressings provide limited therapeutic benefits for chronic wound healing. Effective care for chronic wounds requires a multifunction that integrates exudate management, therapeutic treatment, and continuous monitoring. Here, we introduce an integrated Janus bioelectronic wound care bandage designed to achieve self-pumping exudate management via an electrospinning Janus dressing with opposite wettability, antibacterial properties through silver nanoparticles (AgNPs), and the monitoring of multiplex biomarkers in wounds via electrochemical sensors positioned on the drainage side. The limits of detection (LOD) of sensors are 0.15 mM for glucose, 6.85 μM for UA, and 60.76 mV/decade for pH (4-8), respectively. We demonstrated in mice full-thickness wound models that this bandage effectively promoted wound healing, achieving a wound closure rate of 90.35% on day 14, and monitored the dynamic changes of three biomarkers within wounds in situ over a period of 3 days.