Respiratory Syncytial Virus Humoral Antibody Responses in Older Adults After Vaccination or Infection.
cross_sectional · Level IV
Where this comes from
- Record sourced from PubMed, PMID 40126899.
- Also identified by DOI 10.1093/infdis/jiaf149 and PMC identifier 12247800.
- Licence recorded as CC BY-NC-ND.
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Abstract
Immunity to respiratory syncytial virus (RSV) is short lived following infection. We determined if recently licensed RSV preF vaccines induce better immune responses than infection. Serum preF binding and neutralizing antibody to RSV A and B was measured in older adults at baseline and 30 days after RSV infection or vaccination with 2 licensed RSV preF protein vaccines. Vaccination induced higher serum preF binding antibody and neutralizing responses than RSV infection (A2 RSV, 3306 vs 1254, P < .0001; B1 RSV, 5153 vs 2186, P < .0001). Vaccination with preF protein vaccines induce better humoral immune responses than RSV infection in older adult.
Medical subject headings
- Respiratory Syncytial Virus Infections
- Antibodies, Viral
- Respiratory Syncytial Virus Vaccines
- Respiratory Syncytial Virus, Human
- Immunity, Humoral