Heplisav-B vs Standard Hepatitis B Vaccine Booster for Health Care Workers.
prospective_cohort · Level II
Where this comes from
- Record sourced from PubMed, PMID 40127971.
- Also identified by DOI 10.1370/afm.240184 and PMC identifier 11936371.
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Abstract
Confidence in hepatitis B seroprotection for US health care workers includes a complete immunization series followed by a hepatitis B surface antigen antibody (anti-HBs) titer ≥10 mIU/mL. We compared standard hepatitis B vaccines to Heplisav-B (Dynavax Technologies Corp) as a single booster for young, healthy, previously vaccinated individuals. Participants (N = 242) had documentation of a single vaccination series and an anti-HBs titer <10 mIU/mL. In this cohort, 1 booster achieved seropositivity for 92.7% (95% CI, 84.8%-97.2%) of the standard hepatitis B vaccine group and 99.4% (95% CI, 96.6%-100.0%) of the Heplisav-B group. Both boosters are likely to produce seropositivity in this population.
Medical subject headings
- Hepatitis B Vaccines
- Health Personnel
- Hepatitis B
- Immunization, Secondary
- Hepatitis B Antibodies