Hospitalisations and length of stays in women with endometriosis: a data linkage prospective cohort study.

Gete, Dereje G; Dobson, Annette J; Montgomery, Grant W; Baneshi, Mohammad R; Doust, Jenny; Mishra, Gita D · EClinicalMedicine · 2025

prospective_cohort · Level II

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Abstract

Women with endometriosis have more hospitalisations compared to those without the condition. However, no longitudinal study has examined hospital admission rates and lengths of stay before and after diagnosis. We examined all-cause hospital admissions and lengths of stay among women with, versus without, endometriosis, and before, versus after, diagnosis. This study included 13,501 women of reproductive age, born in 1973-78. The Australian Longitudinal Study on Women's Health survey data linked to administrative health records was used to identify women with endometriosis. Hospital admission rates and length of stays were examined using hospital records of patients admitted up to 2022. Analysis was conducted using mixed-effects zero-inflated negative binomial models. Women with endometriosis were more likely to be admitted to hospitals compared to those without the condition, with an adjusted incidence rate ratio (IRR) of 2.11 (95% CI: 1.83-2.43) for admissions per year. However, they had shorter hospital stays (IRR: 0.90; 0.81-0.99) for days per year and were more often discharged on the same day (odds ratio: 1.27; 1.20-1.33). Post-diagnosis, women experienced more hospitalisations and more days in hospital compared to their pre-diagnosis (IRR: 1.52; 1.22-1.88) and (IRR: 1.81; 1.53-2.14), respectively. Consistent findings were found for women with surgically confirmed or clinically suspected endometriosis. The higher number of hospitalisations among women with endometriosis, compared to those without, highlights the substantial burden of the condition on healthcare utilisation. The persistent frequent hospitalisations and longer stays post-diagnosis indicate recurrent endometriosis, posing significant management challenges. The Australian Longitudinal Study on Women's Health is funded by the Australian Government Department of Health and Aged Care. GDM and GWM are Australian National Health and Medical Research Council Leadership Fellows (GNT2009577 and GNT1177194).