Single cell RNA sequencing shows that cells expressing Sox9 postnatally populate most skeletal lineages in mouse bone.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 40143416.
- Also identified by DOI 10.1093/jbmr/zjaf043.
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Abstract
In growing bones of mice, multiple cell types contribute to the osteoblast lineage, including growth plate chondrocytes, perichondrial cells and CXCL12-abundant reticular marrow stromal cells. Here we use single-cell RNA sequencing and lineage tracing to show that all these osteoblast precursors, even postnatally, derives from Sox9-expressing progenitors. We also characterize a distinct group of chondrocytes located between the perichondrium and the columns of growth plate chondrocytes that contribute to the osteoblast lineage.
Medical subject headings
- SOX9 Transcription Factor
- Cell Lineage
- Single-Cell Analysis
- Sequence Analysis, RNA
- Bone and Bones