Low-Molecular-Weight Heparin Combined With Somatosensory Evoked Potential Monitoring for Prevention of Postoperative Lower Extremity Deep Vein Thrombosis in Patients With Spinal Fracture.

Abstract

To assess the effect of low-molecular-weight heparin (LMWH) combined with evoked potentials somatosensory evoked potential (SEP) on the prevention of deep vein thrombosis (DVT) in patients undergoing spinal surgery. One hundred twenty-eight patients who underwent spinal surgery from August 2022 to August 2023 were chosen, and the patients were randomly classified into the control group and the observation group, with 64 cases in each group. The control group received LMWH injections.The observation group received SEP monitoring on the basis of the control group. The blood flow velocity of popliteal veins of both lower limbs was measured by Color Doppler ultrasonography. The D-dimer concentration was measured using intravenous blood samples taken 1 day before surgery, after surgery, and 24 hours after surgery. The incidence of lower extremity DVT was diagnosed by ultrasonography during surgery and 24 hours after surgery. Compared with the control group, the blood flow velocity of the popliteal veins in both lower limbs in the observation group increased at T2-4 (P < 0.001), and the D-dimer and FIB concentrations in the observation group were decreased (P < 0.001); the occurrence of DVT in the observation group was lower than that in the control group (P < 0.05). LMWH combined with SEP monitoring can effectively prevent the occurrence of lower limb DVT in patients with spinal surgery.