Sound Wave-Activated Self-Powered Adhesive Dressing for Accelerated Wound Healing.

Abstract

Self-powered wound dressings are effective in treating chronic wounds because of their low toxicity and convenience. However, current self-powered dressings rely on the bending movements of the skin or additional large ultrasonic devices. Herein, a flexible adhesive self-powered wound dressing (FASW) that promotes skin regeneration through daily sound wave driving without relying on skin bending or external sound devices is proposed. The FASW dressing consists of a bioadhesive film (BAF), a unidirectional fluorinated conductive film (UFCF), and a liquid metal (LM) interlayer. Benefiting from the cross-linking of chitosan, the dressing exhibits excellent properties, such as biocompatibility, stretchability, tissue adhesion, and recyclability. In vivo experiments show that the FASW dressing reduced inflammation and stimulated hair follicle regeneration. This wound dressing utilizes previously overlooked natural energies for the treatment of chronic wounds, thereby enhancing the therapeutic effect of traditional self-powered dressings on individuals with movement disorders.