CDKN2A Chromogenic In Situ Hybridization for Separating Benign From Malignant Mesothelial Proliferations.

Churg, Andrew; Spence, Tara; Martin, Karina C; Senz, Janine; Yip, Stephen; R Naso, Julia · Am J Surg Pathol · 2025

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Abstract

CDKN2A FISH is a standard method for separating mesotheliomas from reactive mesothelial proliferations, but FISH requires specialized equipment and technical expertise for interpretation. Here, we show that a commercially available CDKN2A CISH probe provides equivalent information but can be easily scored using an ordinary light microscope and does not require specialized training.

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