Infectious Complications in Patients Treated With T-cell Engagers as Cancer Immunotherapies, a Descriptive Study From the REISAMIC Registry.

Hueso, Thomas; Cagnat, Justin; Ouali, Kaïssa; Haberstich, Mathilde; Henry, Benoît; Danu, Alina; Bigenwald, Camille; Merad, Mansouria et al. · Clin Infect Dis · 2025

retrospective_cohort · Level III

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Abstract

We investigated infectious complications and the associated risk factors in 181 patients undergoing T-cell engagers for malignancies. Infections were primarily observed in patients with hematological diseases or heavily pre-treated. Mortality due to infectious complications was 2.8%. Concomitant medications with corticosteroids or tocilizumab did not significantly impact the incidence of infections.

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