Transcriptomic skin niches in systemic sclerosis underpin a role for mitochondrial dysfunction.
Where this comes from
- Record sourced from PubMed, PMID 40172938.
- Also identified by DOI 10.1093/bjd/ljaf119 and PMC identifier 12268033.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Systemic sclerosis (SSc) is a chronic inflammatory disease characterized by fibrosis, vasculopathy and immune dysregulation. Using spatial transcriptomics on the dermis of 11 patients with SSc, we identified distinct transcriptomic niches associated with fibrosis, immune activation and mitochondrial dysfunction. Our findings highlight mitochondrial dysfunction as a central mechanism in SSc pathogenesis, ranging from adaptive remodelling in immune zones to metabolic collapse in fibrotic zones, underscoring mitochondria as a therapeutic target.