Alpha-synuclein seed amplification assays: Data sharing, standardization needed for clinical use.

Lashuel, Hilal A; Surmeier, D James; Simuni, Tanya; Merchant, Kalpana; Caughey, Byron; Soto, Claudio; Fares, Mohamed-Bilal; Heym, Roland G et al. · Sci Adv · 2025

review · Level V

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Abstract

Alpha-synuclein seed amplification assays can improve neurodegenerative disease diagnosis and care, but widespread use depends on a framework that standardizes protocols and encourages data sharing.

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